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Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura is a topic covered in the Johns Hopkins HIV Guide.

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  • Multisystem disease caused by platelet thrombi in various organs.
  • Thrombocytopenia, hemolytic anemia, renal impairment, fever (can be high), and neurologic abnormalities (agitation, disorientation, headache early, late focal deficits, seizure, coma).
  • Rare in HIV, but important to recognize because mortality 60-80% if undiagnosed; mortality < 10% if recognized and treated early.
  • Associated with early and late HIV, malignancy, chemotherapy, pregnancy.
  • Drugs associated with TTP: quinine, ticlopidine, cyclosporine.

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Last updated: February 1, 2015


Moore, Richard D. "Thrombotic Thrombocytopenic Purpura." Johns Hopkins HIV Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545204/all/Thrombotic_thrombocytopenic_purpura.
Moore RD. Thrombotic thrombocytopenic purpura. Johns Hopkins HIV Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545204/all/Thrombotic_thrombocytopenic_purpura. Accessed August 19, 2019.
Moore, R. D. (2015). Thrombotic thrombocytopenic purpura. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545204/all/Thrombotic_thrombocytopenic_purpura
Moore RD. Thrombotic Thrombocytopenic Purpura [Internet]. In: Johns Hopkins HIV Guide. ; 2015. [cited 2019 August 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545204/all/Thrombotic_thrombocytopenic_purpura.
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TY - ELEC T1 - Thrombotic thrombocytopenic purpura ID - 545204 A1 - Moore,Richard,M.D. Y1 - 2015/02/01/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545204/all/Thrombotic_thrombocytopenic_purpura DB - Johns Hopkins Guide DP - Unbound Medicine ER -