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Thrombotic thrombocytopenic purpura
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- Multisystem disease caused by platelet thrombi in various organs.
- Thrombocytopenia, hemolytic anemia, renal impairment, fever (can be high), and neurologic abnormalities (agitation, disorientation, headache early, late focal deficits, seizure, coma).
- Rare in HIV, but important to recognize because mortality 60-80% if undiagnosed; mortality < 10% if recognized and treated early.
- Associated with early and late HIV, malignancy, chemotherapy, pregnancy.
- Drugs associated with TTP: quinine, ticlopidine, cyclosporine.