Thrombotic thrombocytopenic purpura

Richard D. Moore, M.D.

CLINICAL

Multisystem disease caused by platelet thrombi in various organs.
Thrombocytopenia, hemolytic anemia, renal impairment, fever (can be high), and neurologic abnormalities (agitation, disorientation, headache early, late focal deficits, seizure, coma).
Rare in HIV, but important to recognize because mortality 60-80% if undiagnosed; mortality < 10% if recognized and treated early.
Associated with early and late HIV, malignancy, chemotherapy, pregnancy.
Drugs associated with TTP: quinine, ticlopidine, cyclosporine.

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