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Peliosis hepatis is a topic covered in the Johns Hopkins HIV Guide.

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  • Definition: blood filled cavities (lakes) in liver that develop through neo-angiogenesis. Often accompanied by peliosis in the spleen (and also other reticuloendothelial organs - bone, lymph nodes, etc.).
  • Causes: in HIV-positive pts usually caused be infection by Bartonellaspp or TB. In HIV-negative (and some HIV-positive) pts, caused by anabolic steroids, Castleman’s disease, Hodgkin’s lymphoma, leukemia and other malignancies including hepatic tumors, danazol, azithioprine, methotrexate, and other agents.

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Last updated: January 29, 2017


Hoffmann, Christopher J. "Peliosis Hepatis." Johns Hopkins HIV Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545161/6/Peliosis_hepatis.
Hoffmann CJ. Peliosis hepatis. Johns Hopkins HIV Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545161/6/Peliosis_hepatis. Accessed August 17, 2019.
Hoffmann, C. J. (2017). Peliosis hepatis. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545161/6/Peliosis_hepatis
Hoffmann CJ. Peliosis Hepatis [Internet]. In: Johns Hopkins HIV Guide. ; 2017. [cited 2019 August 17]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545161/6/Peliosis_hepatis.
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