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Intravenous immune globulin is a topic covered in the Johns Hopkins HIV Guide.

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  • Bone marrow transplant (to prevent graft vs host disease) CLL
  • Primary immunoglobulin deficiency
  • ITP
  • HIV (prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis) but generally not recommended; Kawasaki disease.
  • VZV post-exposure prophylaxis


  • Anemia due to parvovirus B19 infection
  • Indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
  • Indications that are controversial: patients with streptococcal toxic shock syndrome treated with IVIG had trend toward a lower mortality rate; severe C. difficile colitis (case reports).

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Last updated: March 12, 2011


Pham, Paul A, and John G Bartlett. "Intravenous Immune Globulin." Johns Hopkins HIV Guide, 2011. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545109/all/Intravenous_immune_globulin.
Pham PA, Bartlett JG. Intravenous immune globulin. Johns Hopkins HIV Guide. 2011. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545109/all/Intravenous_immune_globulin. Accessed August 19, 2019.
Pham, P. A., & Bartlett, J. G. (2011). Intravenous immune globulin. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545109/all/Intravenous_immune_globulin
Pham PA, Bartlett JG. Intravenous Immune Globulin [Internet]. In: Johns Hopkins HIV Guide. ; 2011. [cited 2019 August 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545109/all/Intravenous_immune_globulin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Intravenous immune globulin ID - 545109 A1 - Pham,Paul,Pharm.D. AU - Bartlett,John,M.D. Y1 - 2011/03/12/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545109/all/Intravenous_immune_globulin DB - Johns Hopkins Guide DP - Unbound Medicine ER -