Intravenous immune globulin
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- Bone marrow transplant (to prevent graft vs host disease) CLL
- Primary immunoglobulin deficiency
- HIV (prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis) but generally not recommended; Kawasaki disease.
- VZV post-exposure prophylaxis
NON-FDA APPROVED USES
- Anemia due to parvovirus B19 infection
- Indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
- Indications that are controversial: patients with streptococcal toxic shock syndrome treated with IVIG had trend toward a lower mortality rate; severe C. difficile colitis (case reports).