Intravenous immune globulin

Intravenous immune globulin is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

  • Bone marrow transplant (to prevent graft vs host disease) CLL
  • Primary immunoglobulin deficiency
  • ITP
  • HIV (prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis) but generally not recommended; Kawasaki disease.
  • VZV post-exposure prophylaxis

NON-FDA APPROVED USES

  • Anemia due to parvovirus B19 infection
  • Indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
  • Indications that are controversial: patients with streptococcal toxic shock syndrome treated with IVIG had trend toward a lower mortality rate; severe C. difficile colitis (case reports).

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