Intravenous immune globulin

Intravenous immune globulin is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please log in or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

Coronavirus COVID-19 (SARS-CoV-2)Coronavirus COVID-19 (SARS-CoV-2)

COVID-19 December 2020 Update: Therapies and VaccinesCOVID-19 December 2020 Update: Therapies and Vaccines

Moderna COVID-19 VaccineModerna COVID-19 Vaccine

BNT162b2 COVID-19 Vaccine (BioNTech/Pfizer)BNT162b2 COVID-19 Vaccine (BioNTech/Pfizer)

Managing Stress and Coping with COVID-19Managing Stress and Coping with COVID-19

Managing Sleep Problems during COVID-19Managing Sleep Problems during COVID-19

-- The first section of this topic is shown below --

INDICATIONS

FDA

  • Bone marrow transplant (to prevent graft vs host disease)
  • Primary immunoglobulin deficiencies (hypogammaglobulinemia)
  • Idiopathic thrombocytopenic purpura (ITP)
  • Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended)
  • Kawasaki disease
  • VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)

NON-FDA APPROVED USES

  • Autoimmune hemolytic anemias
  • Pure red cell aplasia
  • Guillain-Barre syndrome
  • Steroid resistant dermatomyositis
  • Polymyositis
  • Multifocal motor neuropathy
  • Multiple myeloma
  • Immune-mediated neutropenia
  • Post-transfusion purpura
  • Neonatal alloimmune thrombocytopenia
  • Solid-organ transplant
  • Myasthenia gravis
  • Multiple sclerosis
  • Systemic lupus diseases
  • Systemic vascular syndrome and vasculitis
  • Refractory seizures
  • Chronic inflammatory demyelinating polyneuropathy
  • Stiff person syndrome
  • Paraneoplastic syndrome
  • Thrombocytopenia refractory to platelet transfusion
  • Immune deficiencies and immune regulatory disorders

Infectious Diseases Use

  • Group A Strep TSS
  • Measles post-exposure prophylaxis
  • Adjective therapy for RSV in the severely immunocompromised host (e.g. BMT)
  • Severe C. difficile-associated colitis
  • Anemia due to parvovirus B19 infection
  • CMV infections
  • BK virus nephropathy[1]

-- To view the remaining sections of this topic, please log in or purchase a subscription --

INDICATIONS

FDA

  • Bone marrow transplant (to prevent graft vs host disease)
  • Primary immunoglobulin deficiencies (hypogammaglobulinemia)
  • Idiopathic thrombocytopenic purpura (ITP)
  • Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended)
  • Kawasaki disease
  • VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)

NON-FDA APPROVED USES

  • Autoimmune hemolytic anemias
  • Pure red cell aplasia
  • Guillain-Barre syndrome
  • Steroid resistant dermatomyositis
  • Polymyositis
  • Multifocal motor neuropathy
  • Multiple myeloma
  • Immune-mediated neutropenia
  • Post-transfusion purpura
  • Neonatal alloimmune thrombocytopenia
  • Solid-organ transplant
  • Myasthenia gravis
  • Multiple sclerosis
  • Systemic lupus diseases
  • Systemic vascular syndrome and vasculitis
  • Refractory seizures
  • Chronic inflammatory demyelinating polyneuropathy
  • Stiff person syndrome
  • Paraneoplastic syndrome
  • Thrombocytopenia refractory to platelet transfusion
  • Immune deficiencies and immune regulatory disorders

Infectious Diseases Use

  • Group A Strep TSS
  • Measles post-exposure prophylaxis
  • Adjective therapy for RSV in the severely immunocompromised host (e.g. BMT)
  • Severe C. difficile-associated colitis
  • Anemia due to parvovirus B19 infection
  • CMV infections
  • BK virus nephropathy[1]

There's more to see -- the rest of this entry is available only to subscribers.