HHV-8 is a topic covered in the Johns Hopkins HIV Guide.

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  • Human herpesvirus-8 (HHV-8): human gammaherpes virus, also known as Kaposi’s sarcoma-associated herpesvirus (KSHV)
  • 20-30% of gay men are HHV-8 seropositive vs. 1% of HIV-negative blood donors. Associated with receptive anal intercourse and number of partners. An unknown cofactor may be involved in transmission.
  • HHV-8 gene products promote spindle cell proliferation and angiogenesis and therefore may eventually lead to tumor formation.
  • For diagnostic and specific information see modules Kaposi’s sarcoma, Castlemans disease.

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Last updated: October 31, 2015