HHV-8

Joel N. Blankson, M.D., Ph.D.

MICROBIOLOGY

Human herpesvirus-8 (HHV-8): human gammaherpes virus, also known as Kaposi’s sarcoma-associated herpesvirus (KSHV)
20-30% of men who have sex with men (MSM) are HHV-8 seropositive vs. 1% of HIV-negative blood donors. Associated with receptive anal intercourse and number of partners. An unknown cofactor may be involved in transmission.
HHV-8 gene products promote spindle cell proliferation and angiogenesis and therefore may eventually lead to tumor formation.
For diagnostic and specific information see modules Kaposi’s sarcoma, Castlemans disease.

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