Johns Hopkins HIV Guide
Clindamycin
INDICATIONS
FDA
FDA
- Skin and soft tissue infections caused by streptococci, staphylococci and anaerobes
- Pelvic infections (endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and post-surgical vaginal cuff infections)
- Intra-abdominal infections such as peritonitis and intra-abdominal abscess caused by anaerobes (note: IDSA guideline no longer recommends clindamycin due to increased B. fragilis resistance rate)
- Streptococcus pneumoniae (empyema, pneumonitis, and lung abscess)
- Septicemia (no longer recommended)
- Acne vulgaris (topical gel)
- Bacterial vaginosis in non-pregnant women and pregnant women during the second and third trimesters (intra-vaginal administration)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Alternative treatment of PCP in combination with primaquine
- Alternative treatment of CNS toxoplasmosis in combination with pyrimethamine and leucovorin
- MRSA skin and soft tissue infections
- Necrotizing fasciitis including Fournier gangrene: may be considered in combination with other agents to decrease toxin production caused by MRSA, S. pyogenes, C. perfringens
- Oral abscess in patients with PCN allergies
- Acute bacterial sinusitis
- Intrapartum prophylaxis for Group B strep; alternative to beta-lactam only if susceptibility testing is done
- Bacterial vaginosis
- Actinomycosis
- Osteomyelitis
- Acute bacterial sinusitis
- Non-severe malaria as part of alternative regimen, especially in pregnancy
- Diphtheria
- Alternative therapy for bebesiosis in combination with quinine
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Last updated: July 9, 2018
Citation
Avdic, Edina, and Paul A Pham. "Clindamycin." Johns Hopkins HIV Guide, 2018. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545037/all/Clindamycin.
Avdic E, Pham PA. Clindamycin. Johns Hopkins HIV Guide. 2018. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545037/all/Clindamycin. Accessed September 28, 2023.
Avdic, E., & Pham, P. A. (2018). Clindamycin. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545037/all/Clindamycin
Avdic E, Pham PA. Clindamycin [Internet]. In: Johns Hopkins HIV Guide. ; 2018. [cited 2023 September 28]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545037/all/Clindamycin.
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