Clindamycin is a topic covered in the Johns Hopkins HIV Guide.

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Johns Hopkins Guides

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  • Skin and soft tissue infections caused by streptococci, staphylococci, and anaerobes.
  • Pelvic infections (endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infections)
  • Streptococcus pneumoniae (empyema, pneumonitis, and lung abscess)
  • Septicemia (no longer recommended)
  • Intra-abdominal infections such as peritonitis and intra-abdominal abscess caused by anaerobes (note: IDSA no longer recommends clindamycin due to increased B. fragilis resistance rate)
  • Acne vulgaris (topical gel)
  • Bacterial vaginosis in non-pregnant women (vaginal ovules)


  • PCP in combination with primaquine
  • CNS toxoplasmosis in combination with pyrimethamine and leucovorin
  • Bacterial vaginosis (oral and vaginal ovule)
  • Community acquired MRSA (CA-MRSA) soft tissue infections
  • Osteomyelitis
  • Actinomycosis
  • Acute bacterial sinusitis
  • CA-MRSA pneumonia in combination with vancomycin to reduce toxin production in severe cases.

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Last updated: March 10, 2011