Clindamycin

Edina Avdic, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID

INDICATIONS

Skin and soft tissue infections caused by streptococci, staphylococci and anaerobes
Pelvic infections (endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and post-surgical vaginal cuff infections)
Intra-abdominal infections such as peritonitis and intra-abdominal abscesses caused by anaerobes (note: IDSA guideline no longer recommends clindamycin due to increased B. fragilis resistance rate)
Streptococcus pneumoniae (empyema, pneumonitis, and lung abscess)
Septicemia (no longer recommended)
Acne vulgaris (topical gel)
Bacterial vaginosis in non-pregnant women and pregnant women during the second and third trimesters (intra-vaginal administration)

Alternative treatment of PCP in combination with primaquine
Alternative therapy of CNS toxoplasmosis in combination with pyrimethamine and leucovorin
MRSA skin and soft tissue infections
Necrotizing fasciitis, including Fournier gangrene, may be considered in combination with other agents to decrease toxin production caused by MRSA, S. pyogenes, C. perfringens
Oral abscess in patients with PCN allergies
Acute bacterial sinusitis
Intrapartum prophylaxis for Group B strep; alternative to beta-lactam only if susceptibility testing is done
Bacterial vaginosis
Actinomycosis
Osteomyelitis
Acute bacterial sinusitis
Non-severe malaria as part of the alternative regimen, especially in pregnancy
Diphtheria
Alternative therapy for babesiosis in combination with quinine

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