Clindamycin
Clindamycin is a topic covered in the Johns Hopkins HIV Guide.
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INDICATIONS
FDA
FDA
- Skin and soft tissue infections caused by streptococci, staphylococci and anaerobes
- Pelvic infections (endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and post-surgical vaginal cuff infections)
- Intra-abdominal infections such as peritonitis and intra-abdominal abscess caused by anaerobes (note: IDSA guideline no longer recommends clindamycin due to increased B. fragilis resistance rate)
- Streptococcus pneumoniae (empyema, pneumonitis, and lung abscess)
- Septicemia (no longer recommended)
- Acne vulgaris (topical gel)
- Bacterial vaginosis in non-pregnant women and pregnant women during the second and third trimesters (intra-vaginal administration)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Alternative treatment of PCP in combination with primaquine
- Alternative treatment of CNS toxoplasmosis in combination with pyrimethamine and leucovorin
- MRSA skin and soft tissue infections
- Necrotizing fasciitis including Fournier gangrene: may be considered in combination with other agents to decrease toxin production caused by MRSA, S. pyogenes, C. perfringens
- Oral abscess in patients with PCN allergies
- Acute bacterial sinusitis
- Intrapartum prophylaxis for Group B strep; alternative to beta-lactam only if susceptibility testing is done
- Bacterial vaginosis
- Actinomycosis
- Osteomyelitis
- Acute bacterial sinusitis
- Non-severe malaria as part of alternative regimen, especially in pregnancy
- Diphtheria
- Alternative therapy for bebesiosis in combination with quinine
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