Johns Hopkins Diabetes Guide
Somatostatinoma
DEFINITION
- Rare neuroendocrine tumors (NETs) that arise primarily in the pancreas (from D cells) and duodenum.
- May or may not secrete excess somatostatin, called somatostatinoma syndrome.
- Somatostatin inhibits the secretion of endocrine hormones including insulin which contributes to development of diabetes as well as paracrine hormones including cholecystokinin, vasoactive intestinal peptide (VIP), gastric inhibitory polypeptide (GIP), and pancreatic polypeptide (PP).[17]
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Last updated: June 9, 2020
Citation
Hamrahian, Amir, and Reshmi Srinath. "Somatostatinoma." Johns Hopkins Diabetes Guide, The Johns Hopkins University, 2020. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547136/all/Somatostatinoma.
Hamrahian A, Srinath R. Somatostatinoma. Johns Hopkins Diabetes Guide. The Johns Hopkins University; 2020. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547136/all/Somatostatinoma. Accessed September 27, 2025.
Hamrahian, A., & Srinath, R. (2020). Somatostatinoma. In Johns Hopkins Diabetes Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547136/all/Somatostatinoma
Hamrahian A, Srinath R. Somatostatinoma [Internet]. In: Johns Hopkins Diabetes Guide. The Johns Hopkins University; 2020. [cited 2025 September 27]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547136/all/Somatostatinoma.
* Article titles in AMA citation format should be in sentence-case
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PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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