Somatostatinoma

Amir Hamrahian, M.D., Reshmi Srinath, M.D.

DEFINITION

Rare neuroendocrine tumors (NETs) that arise primarily in the pancreas (from D cells) and duodenum.
May or may not secrete excess somatostatin, called somatostatinoma syndrome.
Somatostatin inhibits the secretion of endocrine hormones including insulin which contributes to development of diabetes as well as paracrine hormones including cholecystokinin, vasoactive intestinal peptide (VIP), gastric inhibitory polypeptide (GIP), and pancreatic polypeptide (PP).[17]

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