Johns Hopkins Diabetes GuideComplications and ComorbiditiesEndocrine

Somatostatinoma

Amin Sabet, M.D., Reshmi Srinath, M.D.
Somatostatinoma is a topic covered in the Johns Hopkins Diabetes Guide.

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DEFINITION

  • Rare somatostatin-producing neuroendocrine tumors (NETs) which arise primarily in the pancreas (from D cells) and duodenum
  • May or may not secrete excess somatostatin, called somatostatin syndrome.
  • Somatostatin inhibits the secretion of endocrine hormones including insulin which contributes to diabetes as well as paracrine hormones including cholecystokinin, VIP, GIP, PP[11]

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Last updated: February 26, 2015