Elderly and Diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

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  • Type 2 diabetes mellitus (T2DM) over the age of 65 years is a major public health problem.
  • Many biological changes likely contribute to increased insulin resistance with aging including: increased abdominal fat mass, decreased physical activity, mitochondrial dysfunction, hormonal changes, increased oxidative stress and inflammation, lower density of the glucose carrier GLUT4 in the muscle [7].
  • Presence of comorbidities, cognitive dysfunction and functional disabilities affect the management of diabetes, especially in the elderly.

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Last updated: August 29, 2015