Elderly and Diabetes
Ana Emiliano, M.D., Rita Rastogi Kalyani, M.D., M.H.S.
- Type 2 diabetes mellitus (T2DM) over the age of 65 years is a major public health problem.
- Many biological changes likely contribute to increased insulin resistance with aging including: increased abdominal fat mass, decreased physical activity, mitochondrial dysfunction, hormonal changes, increased oxidative stress and inflammation, lower density of the glucose carrier GLUT4 in the muscle.
- Presence of comorbidities, cognitive dysfunction and functional disabilities affect the management of diabetes, especially in the elderly.
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