is a topic covered in the Johns Hopkins Diabetes Guide
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- A clouding or opacity of the natural crystalline lens of the eye.
- When glucose increases in the lens (as in hyperglycemic states), the sorbitol pathway is activated more than glycolysis; sorbitol accumulates and is retained in the lens.
- Along with sorbitol, fructose also builds up in a lens surrounded by a high glucose environment.
- These two sugars increase the osmotic pressure within the lens, drawing in water.
- The result is swelling of the lens fibers, disruption of the normal cytoskeletal architecture, and ultimately, lens opacification.
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Last updated: January 3, 2015
Kalyani, Sachin. "Cataracts." Johns Hopkins Diabetes Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547025/all/Cataracts.
Kalyani S. Cataracts. Johns Hopkins Diabetes Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547025/all/Cataracts. Accessed August 25, 2019.
Kalyani, S. (2015). Cataracts. In Johns Hopkins Diabetes Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547025/all/Cataracts
Kalyani S. Cataracts [Internet]. In: Johns Hopkins Diabetes Guide. ; 2015. [cited 2019 August 25]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547025/all/Cataracts.
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