Cataracts
Cataracts is a topic covered in the Johns Hopkins Diabetes Guide.
To view the entire topic, please sign in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
DEFINITION
- A clouding or opacity of the natural crystalline lens of the eye
- When glucose increases in the lens (as in hyperglycemic states), the sorbitol pathway is activated more than glycolysis; sorbitol accumulates and is retained in the lens.
- Along with sorbitol, fructose also builds up in a lens surrounded by a high-glucose environment.
- These two sugars increase the osmotic pressure within the lens, drawing in water.
- The result is swelling of the lens fibers, disruption of the normal cytoskeletal architecture, and ultimately, lens opacification[6].
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
DEFINITION
- A clouding or opacity of the natural crystalline lens of the eye
- When glucose increases in the lens (as in hyperglycemic states), the sorbitol pathway is activated more than glycolysis; sorbitol accumulates and is retained in the lens.
- Along with sorbitol, fructose also builds up in a lens surrounded by a high-glucose environment.
- These two sugars increase the osmotic pressure within the lens, drawing in water.
- The result is swelling of the lens fibers, disruption of the normal cytoskeletal architecture, and ultimately, lens opacification[6].
There's more to see -- the rest of this entry is available only to subscribers.