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- Frequent: Escherichia coli (80-85%)
- Less common but not rare: Staphylococcus saprophyticus, Group B Streptococcus, other Enterobacteriaceae, Enterococcus spp.
- Uncommon: P. aeruginosa, group D streptococci, Ureaplasma spp., Mycoplasma spp., H. influenzae, M. tuberculosis
- Chlamydia trachomatis can cause urethritis with dysuria and pyuria but is not associated with cystitis or acute pyelonephritis.