Posaconazole
Posaconazole is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Prophylaxis of invasiveAspergillus and disseminated candidiasis in severely immunocompromised hosts
- Such as hematopoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations.
- Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of invasive fungal infections (aspergillosis, histoplasmosis, coccidioidomycosis, candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
- Maintenance therapy for Mucorales in patients whose infection has been controlled with standard therapy (e.g., liposomal amphotericin B +/- surgery)
- Alternative treatment of infections due to hyaline fungi (e.g. Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.).
- Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
- Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi.
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INDICATIONS
FDA
FDA
- Prophylaxis of invasiveAspergillus and disseminated candidiasis in severely immunocompromised hosts
- Such as hematopoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations.
- Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of invasive fungal infections (aspergillosis, histoplasmosis, coccidioidomycosis, candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
- Maintenance therapy for Mucorales in patients whose infection has been controlled with standard therapy (e.g., liposomal amphotericin B +/- surgery)
- Alternative treatment of infections due to hyaline fungi (e.g. Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.).
- Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
- Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi.
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Last updated: May 8, 2020
Citation
Avdic, Edina, and Shmuel Shoham. "Posaconazole." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540448/all/Posaconazole.
Avdic E, Shoham S. Posaconazole. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540448/all/Posaconazole. Accessed January 27, 2023.
Avdic, E., & Shoham, S. (2020). Posaconazole. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540448/all/Posaconazole
Avdic E, Shoham S. Posaconazole [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2023 January 27]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540448/all/Posaconazole.
* Article titles in AMA citation format should be in sentence-case
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T1 - Posaconazole
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A1 - Avdic,Edina,Pharm.D.
AU - Shoham,Shmuel,M.D.
Y1 - 2020/05/08/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540448/all/Posaconazole
PB - The Johns Hopkins University
DB - Johns Hopkins Guide
DP - Unbound Medicine
ER -