Posaconazole
Posaconazole is a topic covered in the Johns Hopkins ABX Guide.
To view the entire topic, please log in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
INDICATIONS
FDA
FDA
- Prophylaxis of invasiveAspergillus and disseminated candidiasis in severely immunocompromised hosts
- Such as hematopoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations.
- Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of invasive fungal infections (aspergillosis, histoplasmosis, coccidioidomycosis, candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
- Maintenance therapy for Mucorales in patients whose infection has been controlled with standard therapy (e.g., liposomal amphotericin B +/- surgery)
- Alternative treatment of infections due to hyaline fungi (e.g. Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.).
- Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
- Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi.
-- To view the remaining sections of this topic, please log in or purchase a subscription --
INDICATIONS
FDA
FDA
- Prophylaxis of invasiveAspergillus and disseminated candidiasis in severely immunocompromised hosts
- Such as hematopoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations.
- Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of invasive fungal infections (aspergillosis, histoplasmosis, coccidioidomycosis, candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
- Maintenance therapy for Mucorales in patients whose infection has been controlled with standard therapy (e.g., liposomal amphotericin B +/- surgery)
- Alternative treatment of infections due to hyaline fungi (e.g. Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.).
- Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
- Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi.
There's more to see -- the rest of this entry is available only to subscribers.
© 2000–2021 Unbound Medicine, Inc. All rights reserved