Johns Hopkins ABX Guide
Ketoconazole
INDICATIONS
FDA
FDA
- Systemic
- Treatment of blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
- Note: despite FDA approval, due to the potential for severe hepatitis, adrenal insufficiency, and drug-drug interactions, systemic ketoconazole should not be used as a first-line treatment for any fungal infections.
- Treatment of blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
- Ketoconazole cream 2%
- Treatment of tinea corporis, tinea cruris and tinea pedis caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum
- Treatment of tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare)
- Treatment of cutaneous candidiasis caused by Candida spp.
- Treatment of seborrheic dermatitis.
- Ketoconazole shampoo 2%
- Treatment of tinea (pityriasis) versicolor caused by or presumed to be caused by Pityrosporum orbiculare (also known as Malassezia furfur or M. orbiculare).
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Treatment of hyperadrenalism
- Booster for calcineurin inhibitor to increase levels in solid organ transplant recipients
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Last updated: October 10, 2021
Citation
Avdic, Edina. "Ketoconazole." Johns Hopkins ABX Guide, The Johns Hopkins University, 2021. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540300/all/Ketoconazole.
Avdic E. Ketoconazole. Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540300/all/Ketoconazole. Accessed November 4, 2025.
Avdic, E. (2021). Ketoconazole. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540300/all/Ketoconazole
Avdic E. Ketoconazole [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. [cited 2025 November 04]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540300/all/Ketoconazole.
* Article titles in AMA citation format should be in sentence-case
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