Johns Hopkins ABX Guide
Daptomycin
Daptomycin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomcyin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[5]
- Note: daptomycin should not be used for treatment of pneumonia
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomcyin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[5]
- Note: daptomycin should not be used for treatment of pneumonia
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Last updated: April 8, 2019
Citation
Avdic, Edina. "Daptomycin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
Avdic E. Daptomycin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin. Accessed January 19, 2020.
Avdic, E. (2019). Daptomycin. In Johns Hopkins ABX Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin
Avdic E. Daptomycin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2020 January 19]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
* Article titles in AMA citation format should be in sentence-case
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