Johns Hopkins ABX Guide
Daptomycin
INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms, including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
- VRE infections, including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[16]
- Note: daptomycin should not be used for the treatment of pneumonia
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Last updated: March 16, 2025
Citation
, Caitlin Soto, PharmD, BCIDP, and Edina Avdic. "Daptomycin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2025. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
C, Avdic E. Daptomycin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin. Accessed November 3, 2025.
, C., & Avdic, E. (2025). Daptomycin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin
C, Avdic E. Daptomycin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. [cited 2025 November 03]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin.
* Article titles in AMA citation format should be in sentence-case
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T1 - Daptomycin
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Y1 - 2025/03/16/
BT - Johns Hopkins ABX Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540155/all/Daptomycin
PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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