Daptomycin
Daptomycin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[9]
- Note: daptomycin should not be used for the treatment of pneumonia
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INDICATIONS
FDA
FDA
- Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms including MSSA and MRSA).
- S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
- VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
- Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[9]
- Note: daptomycin should not be used for the treatment of pneumonia
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