Cidofovir is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Treatment of CMV retinitis in pts with AIDS.
    • Approval is based on three Phase II/III trials.
    • The safety and efficacy of the drug have not been proven for CMV-related pneumonia, GI disease, congenital infection or neonatal disease. It also has not garnered approval for use in non-HIV infected persons.

NON-FDA APPROVED USES

  • Treatment of CMV colitis and pneumonitis (efficacy not established).
  • Treatment of acyclovir-resistant HSV.
  • Treatment of adenovirus infection in severely immune compromised.
  • Local injection (plus surgery) in recurrent respiratory papillomatosis (HPV)

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INDICATIONS

FDA

  • Treatment of CMV retinitis in pts with AIDS.
    • Approval is based on three Phase II/III trials.
    • The safety and efficacy of the drug have not been proven for CMV-related pneumonia, GI disease, congenital infection or neonatal disease. It also has not garnered approval for use in non-HIV infected persons.

NON-FDA APPROVED USES

  • Treatment of CMV colitis and pneumonitis (efficacy not established).
  • Treatment of acyclovir-resistant HSV.
  • Treatment of adenovirus infection in severely immune compromised.
  • Local injection (plus surgery) in recurrent respiratory papillomatosis (HPV)

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Last updated: January 13, 2023