Johns Hopkins HIV Guide

CMV, gastrointestinal

PATHOGENS

  • A member of the Betaherpesviridae, double-stranded DNA virus; up to 60-100% seroprevalence. Most infections asymptomatic, virus shed in absence of Sx. Severe disease seen in fetus, AIDS, and immunosuppressed.
  • Transmitted vertically, sexually or by close contact (family members, daycare) via blood , tears, saliva, breast milk, urine, cervical secretions and semen.
  • Establishes permanent latent infection in host.
  • Both primary and secondary infections (reactivation of latent infection or reinfection with another strain) occur. Most cases in immunosuppressed adults tend to be reactivation.

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