Johns Hopkins Antibiotic (ABX) Guide

Morganella

MICROBIOLOGY

  • Facultative anaerobic Gram negative rod. Non-lactose fermenter in the same family as Proteus.
  • Morganella only has single member in its genus M. morganii, and two subspecies: M. morganii and M. sibonii, which differ only in trehalose fermentation.
  • Naturally resistant to penicillin, 1st-2nd generation cephalosporins, macrolides, sulfamethoxazole .
  • Generally sensitive to aminoglycosides, piperacillin, ticarcillin, 3rd-4th gen cephalosporins, carbapenems, quinolones.
  • Tigecycline not reliably effective due to ArcAB efflux pump, although may show synergy in vitro with other antimicrobials (see Vouillamez ref).

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