Long-acting injectables (LAIs)
DEFINITION
- LAIs represent a solution to patients with adherence issues, which is an issue prevalent in patients who require antipsychotic maintenance therapy. Originally thought to only be pertinent to patients with more severe and long-standing psychiatric conditions, LAIs are now seen as options even for patients with first-episode psychosis.
- Initiation of LAIs requires patients to be established on an oral regimen prior to switch, and patient may need oral overlap depending on the formulation that is selected.
- Monitoring of patients with LAIs should not differ from that of their oral antipsychotic counterparts.
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Last updated: October 3, 2025
Citation
Qureshi, Imran. "Long-acting Injectables (LAIs)." Johns Hopkins Psychiatry Guide, The Johns Hopkins University, 2025. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787419/all/Long_acting_injectables__LAIs_.
Qureshi I. Long-acting injectables (LAIs). Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787419/all/Long_acting_injectables__LAIs_. Accessed October 8, 2025.
Qureshi, I. (2025). Long-acting injectables (LAIs). In Johns Hopkins Psychiatry Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787419/all/Long_acting_injectables__LAIs_
Qureshi I. Long-acting Injectables (LAIs) [Internet]. In: Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. [cited 2025 October 08]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787419/all/Long_acting_injectables__LAIs_.
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