Chronic Traumatic Encephalopathy

Bharat R. Narapareddy, M.D., Matthew E. Peters, M.D.
Chronic Traumatic Encephalopathy is a topic covered in the Johns Hopkins Psychiatry Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --


  • Chronic traumatic encephalopathy (CTE) is defined as a distinctive neurodegenerative disease that occurs as a result of repetitive head impact.[1]
    • CTE is a unique tauopathy originally described in boxers.
    • In recent times, CTE has been described in a variety of contact sports, such as American football.
    • In addition, CTE has been seen in military veterans and others exposed to repetitive brain injury.
  • CTE was originally studied in boxers in the 1920s by a forensic pathologist, Martland, who coined the term “Punch Drunk Syndrome.”[2]
  • In 1937, the term evolved and Millspaugh coined "Dementia Puglistica" to describe the posttraumatic sequelae of boxing.[3]
  • In 1962, the term was further amended by Courville who named it “the psychopathic deterioration of pugilists.”[4]
  • In 1973, the neuropathology of CTE was first described by Corsellis in a case series of 15 retired boxers.[5]
  • In 2005, Omalu’s autopsy report of former National Football League (NFL) player Mike Webster led to a greater emphasis on studying repetitive head trauma and concern for CTE as a result of playing American football.[6]

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: October 5, 2018