Chronic Traumatic Encephalopathy
DEFINITION
- Chronic traumatic encephalopathy (CTE) is a progressive tauopathy resulting from repetitive head impacts.[1] Historically described in boxers, CTE is now identified in various contact sports (football, rugby, soccer), military personnel, and other individuals with repetitive brain trauma exposure.
- Historical context
- CTE was originally studied in boxers in the 1920s by a forensic pathologist, Martland, who coined the term “Punch Drunk Syndrome.”[2]
- In 1937, the term evolved and Millspaugh coined "Dementia Puglistica" to describe the posttraumatic sequelae of boxing.[3]
- In 1962, the term was further amended by Courville who named it “the psychopathic deterioration of pugilists.”[4]
- In 1973, the neuropathology of CTE was first described by Corsellis in a case series of 15 retired boxers.[5]
- In 2005, Omalu’s autopsy report of former National Football League (NFL) player Mike Webster led to a greater emphasis on studying repetitive head trauma and concern for CTE as a result of playing American football.[6]
- New 2023 neuropatholical criteria:[7] The minimum threshold for postmortem neuropathological diagnosis of CTE is the presence of a single pathognomonic lesion—perivascular accumulation of hyperphosphorylated tau (p-tau) in neurons, astrocytes, and neurites, particularly in the depths of cortical sulci.
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Last updated: October 4, 2025
Citation
Salfi, Nicole, et al. "Chronic Traumatic Encephalopathy." Johns Hopkins Psychiatry Guide, The Johns Hopkins University, 2025. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787371/all/Chronic_Traumatic_Encephalopathy.
Salfi N, Narapareddy BR, Peters ME. Chronic Traumatic Encephalopathy. Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787371/all/Chronic_Traumatic_Encephalopathy. Accessed October 7, 2025.
Salfi, N., Narapareddy, B. R., & Peters, M. E. (2025). Chronic Traumatic Encephalopathy. In Johns Hopkins Psychiatry Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787371/all/Chronic_Traumatic_Encephalopathy
Salfi N, Narapareddy BR, Peters ME. Chronic Traumatic Encephalopathy [Internet]. In: Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. [cited 2025 October 07]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787371/all/Chronic_Traumatic_Encephalopathy.
* Article titles in AMA citation format should be in sentence-case
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T1 - Chronic Traumatic Encephalopathy
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A1 - Salfi,Nicole,M.D.
AU - Narapareddy,Bharat,M.D.
AU - Peters,Matthew,M.D.
Y1 - 2025/10/04/
BT - Johns Hopkins Psychiatry Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787371/all/Chronic_Traumatic_Encephalopathy
PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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