Tags

Type your tag names separated by a space and hit enter

Prion Disease

Ophelia Yin, Chiadi Onyike‎, M.D.
Prion Disease is a topic covered in the Johns Hopkins Psychiatry Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

DEFINITION

  • Prion diseases are rare and invariably fatal neurodegenerative disorders caused by transmissible misfolded prion proteins.
    • The "prion protein" that causes all known mammalian prion diseases is a misfolded form of protease-resistant protein (PRP).
    • The endogenous, properly folded form is PRPc (for Common or Cellular), whereas the misfolded protein is PRPsc (for SCrapie).
  • Collectively these are known as transmissible spongiform encephalopathies.
    • They primarily affect the central nervous system of humans and other mammals.
    • Discussed here are Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob disease, kuru, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia.
  • The condition may be hereditary, idiopathic, or acquired through exposure to affected tissues or contaminated surgical instruments.
  • Cognitive impairment due to prion disease is classified under the neurocognitive disorders (NCDs) section of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)[1].

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: February 26, 2017

Citation

Yin, Ophelia, and Chiadi Onyike‎. "Prion Disease." Johns Hopkins Psychiatry Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787113/all/Prion_Disease.
Yin O, Onyike‎ C. Prion Disease. Johns Hopkins Psychiatry Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787113/all/Prion_Disease. Accessed August 21, 2019.
Yin, O., & Onyike‎, C. (2017). Prion Disease. In Johns Hopkins Psychiatry Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787113/all/Prion_Disease
Yin O, Onyike‎ C. Prion Disease [Internet]. In: Johns Hopkins Psychiatry Guide. ; 2017. [cited 2019 August 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787113/all/Prion_Disease.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Prion Disease ID - 787113 A1 - Yin,Ophelia, AU - Onyike‎,Chiadi,M.D. Y1 - 2017/02/26/ BT - Johns Hopkins Psychiatry Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787113/all/Prion_Disease DB - Johns Hopkins Guide DP - Unbound Medicine ER -