Hallucinogen-Related Disorders
DEFINITION
- A group of substance-related disorders involving the ingestion of drugs classified broadly as hallucinogens
- In the DSM, hallucinogens are subdivided into two main categories: - Phencyclidine: Used for phencyclidine (PCP) and related compounds including: ketamine, cyclohexamine, and dizocilpine
- Other hallucinogen: Used for all other hallucinogens including phenylalkylamines (e.g., mescaline, DOM, and MDMA), indoleamines (e.g. psilocybin and DMT), ergolines (e.g., LSD and morning glory seeds), and phenethylamines (e.g., 25I-NBOMe)
 
- Disorders caused by PCP and related compounds include: - Phencyclidine-use disorder: Pattern of phencyclidine (PCP) or related substance (e.g., ketamine) use causing significant concern or harm, and decrease in functioning
- Phencyclidine intoxication: Behavioral effects occurring after ingestion of PCP or a related substance (e.g., ketamine)
- Other phencyclidine-induced disorders: - PCP-induced psychotic disorder (see schizophrenia spectrum), PCP-induced depressive disorder, PCP-induced bipolar affective disorder, PCP-induced anxiety disorder, PCP-induced intoxication delirium
 
- Unspecified phencyclidine-related disorder: A PCP-related disorder causing significant concern or harm, and decrease in functioning, not meeting full criteria for any particular PCP-related disorders
 
- Disorders caused by other hallucinogens include: - Other hallucinogen-use disorder: Pattern of "other hallucinogen" use causing significant concern or harm, and decrease in functioning
- Other hallucinogen intoxication: Behavioral or psychological effects occurring after ingestion of a hallucinogen (other than PCP).
- Other hallucinogen-induced disorders - Other hallucinogen-induced psychotic disorder (see schizophrenia spectrum), other hallucinogen-induced depressive disorder, other hallucinogen-induced bipolar affective disorder, other hallucinogen-induced anxiety disorder, other hallucinogen intoxication delirium
 
- Unspecified hallucinogen-related disorder: A hallucinogen-related disorder causing significant concern or harm, and decrease in functioning, not meeting full criteria for any specific other hallucinogen-related disorders
 
- Hallucinogen persisting perception disorder - Re-experiencing while sober the perceptual (often visual) disturbances experienced when an individual was intoxicated with a hallucinogen
 
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Last updated: October 3, 2025
Citation
Marazzi, Lauren, et al. "Hallucinogen-Related Disorders." Johns Hopkins Psychiatry Guide, The Johns Hopkins University, 2025. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787099/all/Hallucinogen_Related_Disorders. 
Marazzi L, Garcia-Romeu A, Hammond AS, Antoine D. Hallucinogen-Related Disorders. Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787099/all/Hallucinogen_Related_Disorders. Accessed October 30, 2025.
Marazzi, L., Garcia-Romeu, A., Hammond, A. S., & Antoine, D. (2025). Hallucinogen-Related Disorders. In Johns Hopkins Psychiatry Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787099/all/Hallucinogen_Related_Disorders
Marazzi L, Garcia-Romeu A, Hammond AS, Antoine D. Hallucinogen-Related Disorders [Internet]. In: Johns Hopkins Psychiatry Guide. The Johns Hopkins University; 2025. [cited 2025 October 30]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787099/all/Hallucinogen_Related_Disorders.
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 Johns Hopkins Psychiatry Guide
Johns Hopkins Psychiatry Guide

