Remdesivir

Kathryn Dzintars, Pharm.D., BCPS, Edina Avdic, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS
Remdesivir is a topic covered in the Johns Hopkins HIV Guide.

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INDICATIONS

FDA

  • Remdesivir is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and pediatric patients (28 days of age and older, and who weigh at least 3 kg) who:
    • Require hospitalization
    • Have positive results of direct SARS-CoV-2 viral testing, who are not hospitalized, have mild to moderate symptoms, and are at high risk for progression to severe COVID-19, including hospitalization or death
  • Severe disease is defined as:
    • Patients with SpO2 ≤ 94% on room air, OR
    • Requiring supplemental oxygen, OR
    • Requiring mechanical ventilation, OR
    • Requiring extracorporeal membrane oxygenation (ECMO)

NON-FDA APPROVED USES

  • Nonhospitalized patients who are at high risk for disease progression may be given a 3-day course of remdesivir (200 mg IV on day 1, then 100 mg IV on days 2 and 3).

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INDICATIONS

FDA

  • Remdesivir is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and pediatric patients (28 days of age and older, and who weigh at least 3 kg) who:
    • Require hospitalization
    • Have positive results of direct SARS-CoV-2 viral testing, who are not hospitalized, have mild to moderate symptoms, and are at high risk for progression to severe COVID-19, including hospitalization or death
  • Severe disease is defined as:
    • Patients with SpO2 ≤ 94% on room air, OR
    • Requiring supplemental oxygen, OR
    • Requiring mechanical ventilation, OR
    • Requiring extracorporeal membrane oxygenation (ECMO)

NON-FDA APPROVED USES

  • Nonhospitalized patients who are at high risk for disease progression may be given a 3-day course of remdesivir (200 mg IV on day 1, then 100 mg IV on days 2 and 3).

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Last updated: May 24, 2022