Coronary Artery Disease
Coronary Artery Disease is a topic covered in the Johns Hopkins HIV Guide.
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PATHOGENS
- HIV infection appears to increase coronary atherosclerosis and risk of acute coronary syndromes (ACS): 1.1 to 1.6x increased risk; 6-15% of deaths among HIV+ in U.S. and Europe caused by cardiovascular disease
- Proposed mechanisms: HIV-mediated inflammation, coagulation disorders, lipid disturbances, gut translocation, and exposure to specific ART agents
- ART agents associated with increased ACS risk (LPV/r, IDV, ABC, ddI) and increased cholesterol: greatest increase in cholesterol (>20mg/dL) with LPV/r, /r, NFV, TPV/r
- Traditional risk factors:
- Hypercholesterolemia and low HDL
- Hypertension
- Diabetes
- Central obesity
- Genetics (family history of MI < 55 yrs)
- Advancing age
- Behavioral factors
- Smoking
- Recreational drug use (especially cocaine)
- Lack of exercise
- Poor food choices
-- To view the remaining sections of this topic, please log in or purchase a subscription --
PATHOGENS
- HIV infection appears to increase coronary atherosclerosis and risk of acute coronary syndromes (ACS): 1.1 to 1.6x increased risk; 6-15% of deaths among HIV+ in U.S. and Europe caused by cardiovascular disease
- Proposed mechanisms: HIV-mediated inflammation, coagulation disorders, lipid disturbances, gut translocation, and exposure to specific ART agents
- ART agents associated with increased ACS risk (LPV/r, IDV, ABC, ddI) and increased cholesterol: greatest increase in cholesterol (>20mg/dL) with LPV/r, /r, NFV, TPV/r
- Traditional risk factors:
- Hypercholesterolemia and low HDL
- Hypertension
- Diabetes
- Central obesity
- Genetics (family history of MI < 55 yrs)
- Advancing age
- Behavioral factors
- Smoking
- Recreational drug use (especially cocaine)
- Lack of exercise
- Poor food choices
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Last updated: January 5, 2017
Citation
Hoffmann, Christopher J. "Coronary Artery Disease." Johns Hopkins HIV Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545238/all/Coronary_Artery_Disease.
Hoffmann CJ. Coronary Artery Disease. Johns Hopkins HIV Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545238/all/Coronary_Artery_Disease. Accessed January 27, 2023.
Hoffmann, C. J. (2017). Coronary Artery Disease. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545238/all/Coronary_Artery_Disease
Hoffmann CJ. Coronary Artery Disease [Internet]. In: Johns Hopkins HIV Guide. ; 2017. [cited 2023 January 27]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545238/all/Coronary_Artery_Disease.
* Article titles in AMA citation format should be in sentence-case
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T1 - Coronary Artery Disease
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Y1 - 2017/01/05/
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