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    Wasting

    Christopher J. Hoffmann, M.D., M.P.H.
    Wasting is a topic covered in the Johns Hopkins HIV Guide.

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    CLINICAL

    • Wasting: Unintentional weight loss >10%; may also be defined by unintentional weight loss >5% over 3 months or a BMI < 18.5.
    • Wasting syndrome: Unintentional weight loss >10% plus diarrhea or chronic weakness and documented fever for ≥30 days.
    • Wasting syndrome is an AIDS-defining condition (category C); wasting is evidence of symptomatic HIV infection (category B).
    • Seen during critical illness and hospitalization, may prolong convalescence.
    • Likely multifactorial related to a proinflammatory state (with potential associated anorexia), hypogonadism, and malabsorption.
    • Must be differentiated from lipoatrophy, which is isolated fat loss (see Lipodystrophy). Wasting/weight loss is consequence of AIDS disease progression and OIs, while lipoatrophy often seen in pts on some less used ART regimens.

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    Last updated: July 31, 2016

    Citation

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    TY - ELEC T1 - Wasting ID - 545221 A1 - Hoffmann,Christopher,M.D., M.P.H. Y1 - 2016/07/31/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545221/all/Wasting DB - Johns Hopkins Guide DP - Unbound Medicine ER -