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Khalil G. Ghanem, M.D., Lisa A. Spacek, M.D., Ph.D.
Syphilis is a topic covered in the Johns Hopkins HIV Guide.

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  • Treponema pallidum subsp. pallidum: a microaerophilic spirochete and etiology of venereal syphilis, a chronic infectious disease
    • Invades CNS and causes congenital infection, unlike endemic treponematoses
  • Endemic (i.e., nonvenereal) treponematoses: T. pallidum subsp. pertenue → yaws; T. carateum → pinta; T. pallidum subsp. endemicum → bejel.
    • Acquisition at a younger age, primary lesion occurs on extremity

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Last updated: October 30, 2014


Ghanem, Khalil G, and Lisa A Spacek. "Syphilis." Johns Hopkins HIV Guide, 2014. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545197/all/Syphilis.
Ghanem KG, Spacek LA. Syphilis. Johns Hopkins HIV Guide. 2014. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545197/all/Syphilis. Accessed July 24, 2019.
Ghanem, K. G., & Spacek, L. A. (2014). Syphilis. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545197/all/Syphilis
Ghanem KG, Spacek LA. Syphilis [Internet]. In: Johns Hopkins HIV Guide. ; 2014. [cited 2019 July 24]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545197/all/Syphilis.
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