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Streptococcus pneumoniae

Streptococcus pneumoniae is a topic covered in the Johns Hopkins HIV Guide.

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  • Streptococcus pneumoniae (pneumococcus): Gram-positive diplococcus with polysaccharide capsule, demonstrated by Quellung reaction or capsular swelling when antibodies bind to capsular polysaccharide antigen.
  • Ecologic niche is nasopharynx, colonizes 5-10% of adults, 20-40% of children.
    • Definite pathogen when isolated from sterile site (blood, CSF, pleural or joint fluid).
    • Probable pathogen in respiratory specimens (Gram stain or culture) or when urine Ag+ in setting of pneumonia.

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Last updated: December 9, 2015


Spacek, Lisa A. "Streptococcus Pneumoniae." Johns Hopkins HIV Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545195/4.3/Streptococcus_pneumoniae.
Spacek LA. Streptococcus pneumoniae. Johns Hopkins HIV Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545195/4.3/Streptococcus_pneumoniae. Accessed August 17, 2019.
Spacek, L. A. (2015). Streptococcus pneumoniae. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545195/4.3/Streptococcus_pneumoniae
Spacek LA. Streptococcus Pneumoniae [Internet]. In: Johns Hopkins HIV Guide. ; 2015. [cited 2019 August 17]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545195/4.3/Streptococcus_pneumoniae.
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