Resistance testing: phenotype is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please or purchase a subscription.

Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

Johns Hopkins Guides

-- The first section of this topic is shown below --

DEFINITION

  • In phenotypic resistance assays, RT, PR, integrase and envelope gene sequences derived from patient plasma HIV RNA are used to measure HIV replication at different concentrations of ARVs.
  • Phenotypic co-receptor tropism assays detect CCR5, CXCR4, or dual/mixed (D/M)-tropic virus. Viral tropism is the ability of HIV to bind to different co-receptors on target cells to achieve viral entry, used to assess activity of CCR5 antagonist (maraviroc).[6]

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: January 3, 2016