Johns Hopkins HIV Guide
Pyrimethamine
INDICATIONS
FDA
FDA
- Malaria (acute) in combination with sulfadoxine and quinine in the treatment of chloroquine-resistant Plasmodium falciparum malaria.
- Resistance prevalent worldwide; not recommended as a prophylactic agent for travelers to most areas (not available in US).
- Toxoplasmosis (in combination with sulfadiazine OR clindamycin plus leucovorin).
Non-FDA approved uses
Non-FDA approved uses
- Isospora
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Last updated: October 28, 2017
Citation
Smith, Janessa M, and Paul A Pham. "Pyrimethamine." Johns Hopkins HIV Guide, The Johns Hopkins University, 2017. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545175/all/Pyrimethamine.
Smith JM, Pham PA. Pyrimethamine. Johns Hopkins HIV Guide. The Johns Hopkins University; 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545175/all/Pyrimethamine. Accessed October 30, 2025.
Smith, J. M., & Pham, P. A. (2017). Pyrimethamine. In Johns Hopkins HIV Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545175/all/Pyrimethamine
Smith JM, Pham PA. Pyrimethamine [Internet]. In: Johns Hopkins HIV Guide. The Johns Hopkins University; 2017. [cited 2025 October 30]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545175/all/Pyrimethamine.
* Article titles in AMA citation format should be in sentence-case
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T1 - Pyrimethamine
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AU - Pham,Paul,Pharm.D.
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UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545175/all/Pyrimethamine
PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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