Pyrimethamine is a topic covered in the Johns Hopkins HIV Guide.

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  • Malaria (acute) in combination with sulfadoxine and quinine in treatment of chloroquine-resistant Plasmodium falciparum malaria. Resistance prevalent worldwide; not recommended as prophylactic agent for travelers to most areas.
  • Toxoplasmosis (in combination with sulfadiazine or clindamycin plus leucovorin).

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Last updated: November 9, 2011