Progressive multifocal leukoencephalopathy (PML)
Progressive multifocal leukoencephalopathy (PML) is a topic covered in the Johns Hopkins HIV Guide.
To view the entire topic, please sign in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
PATHOGENS
- JC (after patient "JC" John Cunningham) virus is a ubiquitous neurotropic ds-DNA polyomavirus. Infects oligodendrocytes and astrocytes.
- Primarily affects deep and subcortical white matter of brain and can expand into cortical gray matter. Rarely involves spinal cord. Spares optic nerve.[2]
- Virus resides in extraneural reservoirs, i.e., lymphoid tissue, kidney, and bone marrow. Excreted in urine of healthy individuals and those with PML.[5]
- Seroprevalence of 70-80%, antibody not protective, those with deficient cellular response, e.g. HIV/AIDS, organ transplantation, hematologic malignancies, and those receiving immunosuppressive therapies, are at risk for PML.[2]
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
Last updated: October 31, 2015
Citation
Spacek, Lisa A. "Progressive Multifocal Leukoencephalopathy (PML)." Johns Hopkins HIV Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_.
Spacek LA. Progressive multifocal leukoencephalopathy (PML). Johns Hopkins HIV Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_. Accessed October 15, 2019.
Spacek, L. A. (2015). Progressive multifocal leukoencephalopathy (PML). In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_
Spacek LA. Progressive Multifocal Leukoencephalopathy (PML) [Internet]. In: Johns Hopkins HIV Guide. ; 2015. [cited 2019 October 15]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Progressive multifocal leukoencephalopathy (PML)
ID - 545172
A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2015/10/31/
BT - Johns Hopkins HIV Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_
DB - Johns Hopkins Guide
DP - Unbound Medicine
ER -