Progressive multifocal leukoencephalopathy (PML)
Progressive multifocal leukoencephalopathy (PML) is a topic covered in the Johns Hopkins HIV Guide.
To view the entire topic, please log in or purchase a subscription.
Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:
-- The first section of this topic is shown below --
PATHOGENS
- JC virus, a ubiquitous, neurotropic ds-DNA polyomavirus, infects primarily oligodendrocytes, as well as astrocytes and neurons.[2]
- Primarily affects deep and subcortical white matter of brain and can expand into cortical gray matter. Rarely involves spinal cord. Spares optic nerve.[7]
- Virus resides in extraneural reservoirs, i.e., lymphoid tissue, kidney, and bone marrow. Excreted in urine of healthy individuals and those with PML.[10]
- Seroprevalence of 70-80%, antibody not protective, those with deficient cellular response, e.g. HIV/AIDS, organ transplantation, hematologic malignancies, and those receiving immunosuppressive therapies, are at risk for PML.[1]
-- To view the remaining sections of this topic, please log in or purchase a subscription --
PATHOGENS
- JC virus, a ubiquitous, neurotropic ds-DNA polyomavirus, infects primarily oligodendrocytes, as well as astrocytes and neurons.[2]
- Primarily affects deep and subcortical white matter of brain and can expand into cortical gray matter. Rarely involves spinal cord. Spares optic nerve.[7]
- Virus resides in extraneural reservoirs, i.e., lymphoid tissue, kidney, and bone marrow. Excreted in urine of healthy individuals and those with PML.[10]
- Seroprevalence of 70-80%, antibody not protective, those with deficient cellular response, e.g. HIV/AIDS, organ transplantation, hematologic malignancies, and those receiving immunosuppressive therapies, are at risk for PML.[1]
There's more to see -- the rest of this topic is available only to subscribers.
Last updated: August 24, 2021
Citation
Spacek, Lisa A. "Progressive Multifocal Leukoencephalopathy (PML)." Johns Hopkins HIV Guide, 2021. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_.
Spacek LA. Progressive multifocal leukoencephalopathy (PML). Johns Hopkins HIV Guide. 2021. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_. Accessed January 30, 2023.
Spacek, L. A. (2021). Progressive multifocal leukoencephalopathy (PML). In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_
Spacek LA. Progressive Multifocal Leukoencephalopathy (PML) [Internet]. In: Johns Hopkins HIV Guide. ; 2021. [cited 2023 January 30]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Progressive multifocal leukoencephalopathy (PML)
ID - 545172
A1 - Spacek,Lisa,M.D., Ph.D.
Y1 - 2021/08/24/
BT - Johns Hopkins HIV Guide
UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545172/all/Progressive_multifocal_leukoencephalopathy__PML_
DB - Johns Hopkins Guide
DP - Unbound Medicine
ER -