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- HIV-1 and HIV-2 (HIV-2 predominantly found in West Africa; also Mozambique and India).
- HIV-1 divided into 3 groups: M (Main) group (worldwide distribution); O (Outlier) group (primarily West Africa), and N (Non-O, Non-M) group (Cameroon).
- M group further divided into subtypes or clades designated A-K.
- HIV-1 group M subtype B is predominant cause of HIV-1 infection in U.S.
- Majority of HIV sexually transmitted with MSM the major mode in U.S. Heterosexual sex is the major mode globally. Injection drug use and mother-to-child transmission are also important modes of infection.
- A "primary HIV-like" syndrome can occur after discontinuation of ART in 5% of individuals.