Parvovirus B19 is a topic covered in the Johns Hopkins HIV Guide.

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MICROBIOLOGY

  • Viral agent of fifth disease, a childhood exanthem.
  • Exposure leads to antibody response with subsequent resistance to further infection.
  • 80% of all adults have antibodies to the organism; 65% of HIV-infected adults have antibodies (possibly unable to maintain humoral response).
  • Virus has tropism for erythroid precursors in marrow, with pure red blood cell (RBC) aplasia.

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Last updated: February 1, 2015