- Common community-acquired respiratory pathogen. Can also be transmitted vertically from mother to child, and through blood products, bone marrow and solid-organ transplants.
- Roughly 80% of all adults have antibodies to the virus; 65% of HIV-infected adults have antibodies. An inability to maintain the humoral response has been postulated to account for the lower level of antibody detection in PLWH.
- Viral agent of fifth disease, a childhood exanthem.
- Viral exposure typically leads to neutralizing antibody production and viral clearance. In immunocompetent hosts antibody production leads to resistance to further infection.
- Virus has tropism for erythroid precursors in the bone marrow. Infection can progress to pure red blood cell aplasia (PRCA) particularly in immunocompromised patients.
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Last updated: August 7, 2022
Vogt, Samantha, and Richard D Moore. "Parvovirus B19." Johns Hopkins HIV Guide, 2022. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545160/all/Parvovirus_B19.
Vogt S, Moore RD. Parvovirus B19. Johns Hopkins HIV Guide. 2022. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545160/all/Parvovirus_B19. Accessed June 9, 2023.
Vogt, S., & Moore, R. D. (2022). Parvovirus B19. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545160/all/Parvovirus_B19
Vogt S, Moore RD. Parvovirus B19 [Internet]. In: Johns Hopkins HIV Guide. ; 2022. [cited 2023 June 09]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545160/all/Parvovirus_B19.
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