Neisseria gonorrhoeae

Christopher Lippincott, M.D., Khalil G. Ghanem, M.D.
Neisseria gonorrhoeae is a topic covered in the Johns Hopkins HIV Guide.

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  • Non-motile, non-spore-forming, Gram-negative diplococcus
  • Infects cuboidal and columnar epithelium leading to a vigorous inflammatory response
  • Selective growth media (Thayer-Martin & New York City) most common; Cx routinely available in Dx of GC infection in settings that can process specimens appropriately. Swabs from urethral, cervical, rectal, pharyngeal, and ocular sites can be Cx’d.
  • Non-amplified molecular testing, including EIA and DNA hybridization probes, may be used. Cervical and urethral swabs can be tested.
  • Nucleic acid amplification tests (NAATs) are the gold standard and may be performed on urethral swabs, cervical swabs, urine, self-collected vaginal swabs, and rectal and pharyngeal swabs (not FDA approved for rectal and pharyngeal, although excellent test performance).

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Last updated: March 2, 2017