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Neisseria gonorrhoeae

Christopher Lippincott, M.D., Khalil G. Ghanem, M.D.
Neisseria gonorrhoeae is a topic covered in the Johns Hopkins HIV Guide.

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  • Non-motile, non-spore-forming, Gram-negative diplococcus
  • Infects cuboidal and columnar epithelium leading to a vigorous inflammatory response
  • Selective growth media (Thayer-Martin & New York City) most common; Cx routinely available in Dx of GC infection in settings that can process specimens appropriately. Swabs from urethral, cervical, rectal, pharyngeal, and ocular sites can be Cx’d.
  • Non-amplified molecular testing, including EIA and DNA hybridization probes, may be used. Cervical and urethral swabs can be tested.
  • Nucleic acid amplification tests (NAATs) are the gold standard and may be performed on urethral swabs, cervical swabs, urine, self-collected vaginal swabs, and rectal and pharyngeal swabs (not FDA approved for rectal and pharyngeal, although excellent test performance).

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Last updated: March 2, 2017


Lippincott, Christopher, and Khalil G Ghanem. "Neisseria Gonorrhoeae." Johns Hopkins HIV Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545143/all/Neisseria_gonorrhoeae.
Lippincott C, Ghanem KG. Neisseria gonorrhoeae. Johns Hopkins HIV Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545143/all/Neisseria_gonorrhoeae. Accessed July 18, 2019.
Lippincott, C., & Ghanem, K. G. (2017). Neisseria gonorrhoeae. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545143/all/Neisseria_gonorrhoeae
Lippincott C, Ghanem KG. Neisseria Gonorrhoeae [Internet]. In: Johns Hopkins HIV Guide. ; 2017. [cited 2019 July 18]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545143/all/Neisseria_gonorrhoeae.
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TY - ELEC T1 - Neisseria gonorrhoeae ID - 545143 A1 - Lippincott,Christopher,M.D. AU - Ghanem,Khalil,M.D. Y1 - 2017/03/02/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545143/all/Neisseria_gonorrhoeae DB - Johns Hopkins Guide DP - Unbound Medicine ER -