Neisseria gonorrhoeae

Matthew Hamill, M.B.Ch.B., Ph.D., Christopher Lippincott, M.D.
Neisseria gonorrhoeae is a topic covered in the Johns Hopkins HIV Guide.

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MICROBIOLOGY

  • Non-motile, non-spore-forming, Gram-negative diplococcus.
  • Infects cuboidal and columnar epithelium typically leading to a vigorous inflammatory response.
  • Selective growth media (Thayer-Martin & New York City) most common; Cx routinely available in Dx of GC infection in settings that can process specimens appropriately. Swabs from urethral, cervical, rectal, pharyngeal, and ocular sites can be Cx’d.
  • Cx and antimicrobial susceptibility testing necessary when antibiotic resistance is suspected.
  • Nucleic acid amplification tests (NAATs) are the gold standard and may be performed on urethral swabs, cervical swabs, urine, self-collected vaginal swabs, and rectal and pharyngeal swabs.

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MICROBIOLOGY

  • Non-motile, non-spore-forming, Gram-negative diplococcus.
  • Infects cuboidal and columnar epithelium typically leading to a vigorous inflammatory response.
  • Selective growth media (Thayer-Martin & New York City) most common; Cx routinely available in Dx of GC infection in settings that can process specimens appropriately. Swabs from urethral, cervical, rectal, pharyngeal, and ocular sites can be Cx’d.
  • Cx and antimicrobial susceptibility testing necessary when antibiotic resistance is suspected.
  • Nucleic acid amplification tests (NAATs) are the gold standard and may be performed on urethral swabs, cervical swabs, urine, self-collected vaginal swabs, and rectal and pharyngeal swabs.

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Last updated: January 23, 2023