Johns Hopkins Guides provide diagnosis, management, and treatment guidance for infectious diseases, diabetes, and psychiatric conditions. Explore these free sample topics:
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- Often caused by medications: antiretrovirals (esp. RTV, other PIs, AZT), high-dose TMP-SMX, macrolides, opiates.
- Prevention or treatment of nausea important to improve adherence to therapy.
- Initiation of ART: nausea greatest in 1st 1-2 wks of ART. Consider prn antiemetic when starting some regimens.
- Nausea/vomiting may be a sign of a life-threatening reaction to ART: ABC hypersensitivity; NVP hepatotoxicity; lactic acidosis (d4T, ddI, AZT); pancreatitis w/ ddI, especially if combined with d4T (contraindicated), ribavirin (contraindicated) or TDF (reduce dose of ddI).
- Metabolic causes: adrenal insufficiency, uremia, hypercalcemia
- CNS disease: mass lesions, meningitis
- GI disease: gastritis, gastroparesis, reflux esophagitis, PUD, lymphoma, KS, hepatobiliary disease (including drug-induced hepatitis), pancreatitis
- Misc: opiate withdrawal, pregnancy