Type your tag names separated by a space and hit enter

    Lactic Acidosis

    Richard D. Moore, M.D.
    Lactic Acidosis is a topic covered in the Johns Hopkins HIV Guide.

    To view the entire topic, please or purchase a subscription.

    Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. Explore these free sample topics:

    Johns Hopkins Guides

    -- The first section of this topic is shown below --

    CLINICAL

    • Symptoms: Fatigue, weakness, myalgias, and GI distress, including abdominal pain, abdominal distention, nausea/vomiting, diarrhea. Later can advance to dyspnea, orthostasis, organ failure (hepatic, renal), cardiovascular collapse and death.
    • Mortality: 7% with lactate 5-10 mM, 20-30% with lactate 10-15 mM, 50-60% with lactate >15 mM
    • Caused by NRTI use: d4T, ddI, AZT. Does not appear to be caused by 3TC, FTC, ABC, TDF, TAF, though listed in package insert as a class effect. Use of d4T and ddI no longer recommended; occurrence now rare.
    • Associated with mitochondrial DNA gamma polymerase inhibition and decrease in mitochondrial DNA
    • May be accompanied by hepatic steatosis (fatty liver), pancreatitis. Fatal liver failure can occur (earliest reports in AZT-treated patients)
    • Increased risk with lower CD4, older age, female sex.

    -- To view the remaining sections of this topic, please or purchase a subscription --

    Last updated: August 2, 2017

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Lactic Acidosis ID - 545115 A1 - Moore,Richard,M.D. Y1 - 2017/08/02/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545115/all/Lactic_Acidosis DB - Johns Hopkins Guide DP - Unbound Medicine ER -