Human papillomavirus (HPV)

Lisa A. Spacek, M.D., Ph.D.
Human papillomavirus (HPV) is a topic covered in the Johns Hopkins HIV Guide.

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MICROBIOLOGY

  • Non-enveloped, double-stranded DNA virus that infects stratified squamous epithelium.
  • Most infections are self-limited and cleared within 2 yrs. Oncogenic types may persist and cause HPV-infected cells to transform into cancer cells.[10]
  • Persistence of HPV is linked to immunocompromised states, i.e., HIV and transplantation.
    • Cervical cancer is an AIDS-defining malignancy. HPV is known to cause anal, cervical, and vulvovaginal squamous cell cancer.
    • HIV-infected MSM estimated 131 cases/100,000 PY, HIV-infected men 46 cases/100,000PY, and HIV-uninfected men 2 cases/100,000 PY of anal cancer.[17]

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MICROBIOLOGY

  • Non-enveloped, double-stranded DNA virus that infects stratified squamous epithelium.
  • Most infections are self-limited and cleared within 2 yrs. Oncogenic types may persist and cause HPV-infected cells to transform into cancer cells.[10]
  • Persistence of HPV is linked to immunocompromised states, i.e., HIV and transplantation.
    • Cervical cancer is an AIDS-defining malignancy. HPV is known to cause anal, cervical, and vulvovaginal squamous cell cancer.
    • HIV-infected MSM estimated 131 cases/100,000 PY, HIV-infected men 46 cases/100,000PY, and HIV-uninfected men 2 cases/100,000 PY of anal cancer.[17]

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Last updated: October 28, 2017