Johns Hopkins HIV Guide
Herpes zoster
Herpes zoster is a topic covered in the Johns Hopkins HIV Guide.
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PATHOGENS
- Varicella zoster virus (VZV) is an enveloped, double-stranded DNA, human α-herpesviruses.
- After inhalation, VZV proliferates in the tonsils and and is carried to the epidermis where it causes chicken pox. Then, VZV travels via retrograde transport from sensory nerve terminals to dorsal root and cranial nerve ganglia, and establishes lifelong latent infection.[6]
- VZV reactivates in setting of declining cell-mediated immunity in elderly and immunocompromised individuals, producing herpes zoster (HZ).
- >95% of adult U.S. population infected; in 50% of individuals, VZV reactivation results in HZ by 85 years of age.[5]
-- To view the remaining sections of this topic, please log in or purchase a subscription --
PATHOGENS
- Varicella zoster virus (VZV) is an enveloped, double-stranded DNA, human α-herpesviruses.
- After inhalation, VZV proliferates in the tonsils and and is carried to the epidermis where it causes chicken pox. Then, VZV travels via retrograde transport from sensory nerve terminals to dorsal root and cranial nerve ganglia, and establishes lifelong latent infection.[6]
- VZV reactivates in setting of declining cell-mediated immunity in elderly and immunocompromised individuals, producing herpes zoster (HZ).
- >95% of adult U.S. population infected; in 50% of individuals, VZV reactivation results in HZ by 85 years of age.[5]
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Last updated: March 7, 2020
Citation
Spacek, Lisa A. "Herpes Zoster." Johns Hopkins HIV Guide, 2020. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545093/4/Herpes_zoster.
Spacek LA. Herpes zoster. Johns Hopkins HIV Guide. 2020. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545093/4/Herpes_zoster. Accessed March 22, 2023.
Spacek, L. A. (2020). Herpes zoster. In Johns Hopkins HIV Guide https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545093/4/Herpes_zoster
Spacek LA. Herpes Zoster [Internet]. In: Johns Hopkins HIV Guide. ; 2020. [cited 2023 March 22]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545093/4/Herpes_zoster.
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