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Herpes simplex is a topic covered in the Johns Hopkins HIV Guide.

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  • HSV-1 and HSV-2 are double-stranded, enveloped DNA viruses of the α-herpesviruses. Distributed worldwide, HSV-1 and HSV-2 are antigenically distinct. Herpes from Greek "to creep".
  • High rates of seroprevalence to HSV-1 by adulthood, seroprevalence of HSV-2 related to sexual activity. HSV-2 increases risk of HIV acquisition and transmission.
  • A chronic, life-long infection with acute episodes; establishes latency in sensory ganglia at site of initial mucocutaneous infection.

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Last updated: February 1, 2015


Spacek, Lisa A. "Herpes Simplex." Johns Hopkins HIV Guide, 2015. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex.
Spacek LA. Herpes simplex. Johns Hopkins HIV Guide. 2015. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex. Accessed July 16, 2019.
Spacek, L. A. (2015). Herpes simplex. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex
Spacek LA. Herpes Simplex [Internet]. In: Johns Hopkins HIV Guide. ; 2015. [cited 2019 July 16]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545092/all/Herpes_simplex.
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