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- Hepatitis A virus (HAV): non-enveloped, icosahedral, positive-stranded RNA virus
- Spread via fecal-oral route; more prevalent in low and middle-income countries (20-30% of people in U.S. are seropositive).
- Transmission through contaminated food and water (including furits and packaged foods imported into the US) and through some sexual practices (oral-anal & digital-anal sex); multiple sexual partners and MSM are risks.
- Pathogenesis from robust HAV-specific CD8+ T-cell, NK T-cell, and IFN response leading to hepatocyte destruction.
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Last updated: July 31, 2016
Hoffmann, Christopher J. "Hepatitis A." Johns Hopkins HIV Guide, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545088/all/Hepatitis_A.
Hoffmann CJ. Hepatitis A. Johns Hopkins HIV Guide. 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545088/all/Hepatitis_A. Accessed March 21, 2019.
Hoffmann, C. J. (2016). Hepatitis A. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545088/all/Hepatitis_A
Hoffmann CJ. Hepatitis A [Internet]. In: Johns Hopkins HIV Guide. ; 2016. [cited 2019 March 21]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545088/all/Hepatitis_A.
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