Fluconazole
INDICATIONS
FDA
FDA
- Candidiasis prophylaxis (patients undergoing bone marrow transplant who receive cytotoxic chemotherapy and/or radiation therapy)
 - Oropharyngeal and esophageal candidiasis
 - Vulvovaginal candidiasis
 - Cryptococcal meningitis (treatment and suppression) in AIDS patients
 
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Blastomycosis
 - Candida infections 
- Disseminated candidiasis and candidemia (including peritonitis)
 - Endophthalmitis
 - Osteoarticular infection and septic arthritis
 - UTIs
 - Endovascular - step-down therapy
 - CNS candidiasis - step-down therapy
 - Neonatal candidiasis
 - Prophylaxis: critically ill patients s/p GI surgery, candidal infection prevention
 
 - Cryptococcal infections: meningitis (non-HIV) and pulmonary infections (HIV, non-HIV)
 - Coccidioidomycosis
 - Histoplasmosis a 
- As an alternative therapy for mild to moderate diseases in patients intolerant to itraconazole.
 
 - Pityriasis versicolor
 - Tinea infections
 
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Last updated: April 12, 2025
Citation
Dzintars, Kathryn Dzintars, and Edina Avdic. "Fluconazole." Johns Hopkins HIV Guide, The Johns Hopkins University, 2025. Johns Hopkins Guides, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545073/all/Fluconazole. 
Dzintars K, Avdic E. Fluconazole. Johns Hopkins HIV Guide. The Johns Hopkins University; 2025. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545073/all/Fluconazole. Accessed November 3, 2025.
Dzintars, K., & Avdic, E. (2025). Fluconazole. In Johns Hopkins HIV Guide. The Johns Hopkins University. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545073/all/Fluconazole
Dzintars K, Avdic E. Fluconazole [Internet]. In: Johns Hopkins HIV Guide. The Johns Hopkins University; 2025. [cited 2025 November 03]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545073/all/Fluconazole.
* Article titles in AMA citation format should be in sentence-case
TY  -  ELEC
T1  -  Fluconazole
ID  -  545073
A1  -  Dzintars,Kathryn Dzintars,Pharm.D., BCPS
AU  -  Avdic,Edina,Pharm.D.
Y1  -  2025/04/12/
BT  -  Johns Hopkins HIV Guide
UR  -  https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545073/all/Fluconazole
PB  -  The Johns Hopkins University
DB  -  Johns Hopkins Guides
DP  -  Unbound Medicine
ER  -  

Johns Hopkins HIV Guide

