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Entamoeba histolytica

Entamoeba histolytica is a topic covered in the Johns Hopkins HIV Guide.

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  • Protozoan parasite, causes diarrhea, dysentery, invasive intestinal, and extraintestinal disease (e.g., amebic liver abscess).
  • Quadrinucleate cyst passed in feces transmits the infection. Excystation occurs in small intestine. Trophozoites migrate to large intestine and invade mucosa.[9]
    • Galactose/N-acetyl-D-galactosamine (Gal/GalNAc)-specific lectin mediates parasite adhesion to colonic mucin.
    • Invasion related to penetration of mucous layer, killing of epithelial cells by amoebapore (5kDa protein).
    • Deep ulcerations that spread in the submucosa form flask-shaped ulcers and cause microhemorrhages.
  • Immunity mediated by mucosal IgA recognition of Gal/GalNAc lectin.

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Last updated: July 31, 2016


Spacek, Lisa A. "Entamoeba Histolytica." Johns Hopkins HIV Guide, 2016. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545065/all/Entamoeba_histolytica.
Spacek LA. Entamoeba histolytica. Johns Hopkins HIV Guide. 2016. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545065/all/Entamoeba_histolytica. Accessed July 16, 2019.
Spacek, L. A. (2016). Entamoeba histolytica. In Johns Hopkins HIV Guide. Available from https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545065/all/Entamoeba_histolytica
Spacek LA. Entamoeba Histolytica [Internet]. In: Johns Hopkins HIV Guide. ; 2016. [cited 2019 July 16]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545065/all/Entamoeba_histolytica.
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TY - ELEC T1 - Entamoeba histolytica ID - 545065 A1 - Spacek,Lisa,M.D., Ph.D. Y1 - 2016/07/31/ BT - Johns Hopkins HIV Guide UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_HIV_Guide/545065/all/Entamoeba_histolytica DB - Johns Hopkins Guide DP - Unbound Medicine ER -